Identifying genes that increase the risk of autism and their effects on the disorder
Official title: 4/4 - The Autism Sequencing Consortium: Discovering autism risk genes and how they impact core features of the disorder
Funded at University of Oxford · NIH-11002673 · Data updated 2026-11-12
This study is looking at the genes that might play a role in autism to help us understand the condition better, and it's for families and individuals affected by autism who want to learn more about how genetics can influence their experiences.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oxford NIH-funded |
| Lab location | 1 site (Oxford, United Kingdom) |
| Project start | March 1, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $227,804 |
| NIH project number | 5R01MH129751-04 |
| Project ID | NIH-11002673 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with autism spectrum disorder and their family members.
✕Less likely to help
Patients without a diagnosis of autism spectrum disorder or those who do not have a family history of ASD may not benefit from this research.
What this research studies
This research investigates the genetic factors that contribute to autism spectrum disorder (ASD) by analyzing DNA from individuals and families affected by ASD. The Autism Sequencing Consortium is a collaborative effort that aims to identify specific genes associated with autism risk and understand how these genes influence the core features of the disorder. By examining various types of genetic variations, including rare mutations, the research seeks to uncover insights into the biological pathways disrupted in ASD. This could lead to a better understanding of autism and its diverse manifestations.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of autism, potentially leading to improved diagnostic tools and targeted interventions for individuals with ASD.
How similar studies have gone: Previous research by the Autism Sequencing Consortium has successfully identified numerous genes linked to autism, indicating a strong foundation for this ongoing investigation.
Where this research is happening
-
University of Oxford
Oxford, United Kingdom Active
Researchers
- Principal investigator: Sanders, Stephan — University of Oxford
- Study coordinator: Sanders, Stephan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.