Identifying genes that cause allergic airway inflammation using special mice
Official title: QTL mapping with Collaborative Cross mice defines genes that promote allergic airway inflammation
Funded at Vanderbilt University · NIH-11003280 · Data updated 2026-11-12
This study is looking at how certain genes affect asthma caused by allergens like mold, using a special group of mice to see how specific immune cells react to these allergens, which could help us find new ways to treat asthma.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | January 1, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $34,164 |
| NIH project number | 5F30AI176712-02 |
| Project ID | NIH-11003280 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from allergic asthma or related allergic conditions.
✕Less likely to help
Patients with non-allergic asthma or those whose asthma is not influenced by genetic factors may not benefit from this research.
What this research studies
This research investigates how certain genes influence allergic airway inflammation, particularly in asthma triggered by allergens like mold. By using a unique group of genetically diverse mice, the study aims to understand how specific immune cells, known as ILC2, respond to allergens and contribute to inflammation in the lungs. The researchers will map genetic traits associated with the activation and proliferation of these immune cells when exposed to common environmental allergens. This approach could lead to new insights into the mechanisms of asthma and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for asthma and allergic diseases by targeting the underlying genetic factors that drive inflammation.
How similar studies have gone: Previous research has shown success in using genetic mapping approaches to identify factors involved in asthma and allergic responses, indicating that this methodology is promising.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Rusznak, Mark — Vanderbilt University
- Study coordinator: Rusznak, Mark
Related research
Other NIH-funded projects on the same topics.
-
Understanding how peer norms around alcohol and HIV prevention affect adolescents and young adults in rural Uganda
This project studies how what young people think their peers do or approve of influences drinking and HIV prevention behaviors in rural Uganda, with the goal of improving health outcomes.
-
Cancer Pain Management for Asian American Breast Cancer Survivors with Depressive Symptoms
A technology-based program helps Asian American breast cancer survivors with depressive symptoms manage chronic pain more effectively from home using a web app and mobile tools.
-
Targeted gene silencing in the brain using siRNA helpers
This grant tests a new way to turn off specific brain genes in particular CNS cell types using siRNA conjugates to help understand brain biology and disease.
-
RSELVES Study: How older couples influence daily life and function with Alzheimer’s risk
A study to understand how daily routines and support between older adults and their partners relate to the development of Alzheimer’s-related functional decline.
-
Molecular mechanisms of coat assembly and regulation in membrane trafficking
A research project seeks to understand how cellular coats organize and regulate the delivery of membrane-bound cargo, with a focus on proteins related to neurological diseases.
-
Synaptic nanostructure in neurodevelopmental disorders
This project aims to map the tiny architecture of brain synapses in native cells to understand how connections form and change in neurodevelopmental disorders.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.