Identifying genes that affect bone strength and response to treatment
Identification of Genes Regulating PTH-Mediated Skeletal Strength
This study is looking at how our genes affect bone strength and how well older adults with osteoporosis respond to a treatment called Teriparatide, to help figure out why some people don’t see improvements in their bone health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10682591 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that influence bone strength and how individuals respond to a specific bone treatment called Teriparatide. By studying a diverse group of genetic variations, the researchers aim to uncover which genes are involved in regulating the mechanical integrity of bones. This could help explain why some patients do not see improvements in bone density despite treatment. The study focuses on understanding the complex relationship between genetics and bone health, particularly in older adults at risk for osteoporosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those over 50, who are at risk for osteoporosis and may be receiving treatment with Teriparatide.
Not a fit: Patients who are younger than 50 or those without osteoporosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatments for osteoporosis, improving bone health and reducing fracture risk for patients.
How similar studies have performed: Previous research has shown that genetic factors play a significant role in bone health, indicating that this approach has potential for success.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Ackert-Bicknell, Cheryl Lynne — University of Colorado Denver
- Study coordinator: Ackert-Bicknell, Cheryl Lynne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.