Identifying genes linked to PTSD susceptibility in a mouse model
Official title: Identification of genes conferring susceptibility in a preclinical model of PTSD
Funded at James a. Haley VA Medical Center · NIH-10927577 · Data updated 2026-11-12
This study is looking at how our genes might make some people more likely to develop PTSD after going through a tough experience, using mice to help find clues that could lead to better ways to prevent PTSD in those who are at risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James a. Haley VA Medical Center NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | October 1, 2024 |
| Project end | September 30, 2026 |
| Funding year | 2025 |
| NIH project number | 1I21RX005159-01 |
| Project ID | NIH-10927577 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of trauma exposure, particularly military personnel who may be at higher risk for PTSD.
✕Less likely to help
Patients who have not experienced trauma or those with established PTSD who are seeking immediate treatment may not benefit directly from this research.
What this research studies
This research investigates the genetic factors that may make individuals more susceptible to developing post-traumatic stress disorder (PTSD) after experiencing trauma. By using a well-characterized mouse model that simulates the effects of multiple stressors, the researchers aim to identify specific neural cell subpopulations and their genetic profiles associated with PTSD. This approach allows for a controlled environment to study the neurobiological responses to trauma, which can be challenging to assess in human subjects. The ultimate goal is to uncover insights that could lead to tailored preventative interventions for those at risk of PTSD.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention strategies for PTSD, potentially benefiting individuals at risk of developing the disorder.
How similar studies have gone: While the approach of using animal models to study PTSD is established, the specific genetic focus of this research represents a novel angle that has not been extensively tested.
Where this research is happening
-
James a. Haley VA Medical Center
Tampa, United States Active
Researchers
- Principal investigator: Crawford, Fiona C. — James a. Haley VA Medical Center
- Study coordinator: Crawford, Fiona C.
Related research
Other NIH-funded projects on the same topics.
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-
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Identifying brain proteins linked to PTSD and alcohol use disorder
Researchers are studying brain proteins that may contribute to PTSD and alcohol use disorder in US veterans to find new ways to help people who struggle with both conditions.
-
Transdiagnostic Behavior Therapy for Veterans with Social Anxiety and PTSD Symptoms
A clinical trial tests whether a flexible brain-behavior therapy helps veterans with social anxiety and PTSD symptoms feel better and engage more in daily life.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.