Identifying genes linked to disease susceptibility using mouse models
The Mouse Model System for Targeted Trimming of Disease Susceptibility Loci
['FUNDING_R21'] · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · NIH-11118506
This study is looking at how certain genes cause diseases by using mice to help find the right genes, which could lead to better treatments for those conditions.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HENRY M. JACKSON FDN FOR THE ADV MIL/MED (nih funded) |
| Locations | 1 site (BETHESDA, UNITED STATES) |
| Trial ID | NIH-11118506 on ClinicalTrials.gov |
What this research studies
This research focuses on identifying the genes responsible for specific diseases and their traits by using mouse models. The approach involves mapping susceptibility loci and pinpointing the causative genes through advanced techniques like homologous recombination. By generating new mouse lines and crossing them, researchers aim to streamline the identification of these genes, which can be complex due to the size and nature of the loci involved. This method promises to enhance the understanding of disease mechanisms and potentially lead to new therapeutic developments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic predispositions to specific diseases that are being studied.
Not a fit: Patients with diseases not linked to the genetic factors being investigated in this research may not receive any benefit.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for diseases by identifying the underlying genetic causes.
How similar studies have performed: Previous research has shown success in using similar genetic mapping approaches in mouse models to identify disease-related genes.
Where this research is happening
BETHESDA, UNITED STATES
- HENRY M. JACKSON FDN FOR THE ADV MIL/MED — BETHESDA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PETUKHOVA, GALINA — HENRY M. JACKSON FDN FOR THE ADV MIL/MED
- Study coordinator: PETUKHOVA, GALINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.