Identifying genes linked to disease susceptibility using mouse models
Official title: The Mouse Model System for Targeted Trimming of Disease Susceptibility Loci
Funded at Henry M. Jackson Fdn for the Adv Mil/med · NIH-11118506 · Data updated 2026-11-12
This study is looking at how certain genes cause diseases by using mice to help find the right genes, which could lead to better treatments for those conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry M. Jackson Fdn for the Adv Mil/med NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $261,017 |
| NIH project number | 1R21OD038406-01 |
| Project ID | NIH-11118506 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic predispositions to specific diseases that are being studied.
✕Less likely to help
Patients with diseases not linked to the genetic factors being investigated in this research may not receive any benefit.
What this research studies
This research focuses on identifying the genes responsible for specific diseases and their traits by using mouse models. The approach involves mapping susceptibility loci and pinpointing the causative genes through advanced techniques like homologous recombination. By generating new mouse lines and crossing them, researchers aim to streamline the identification of these genes, which can be complex due to the size and nature of the loci involved. This method promises to enhance the understanding of disease mechanisms and potentially lead to new therapeutic developments.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for diseases by identifying the underlying genetic causes.
How similar studies have gone: Previous research has shown success in using similar genetic mapping approaches in mouse models to identify disease-related genes.
Where this research is happening
-
Henry M. Jackson Fdn for the Adv Mil/med
Bethesda, United States Active
Researchers
- Principal investigator: Petukhova, Galina — Henry M. Jackson Fdn for the Adv Mil/med
- Study coordinator: Petukhova, Galina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.