Identifying genes linked to alcohol-related behaviors and disorders
Official title: Leveraging GWAS Findings to Map Variants and Identify Novel Effector Genes for Alcohol-Related Traits
Funded at University of Pennsylvania · NIH-11012413 · Data updated 2026-11-12
This study is looking at how our genes might affect how much alcohol we drink and the problems that can come from it, using advanced techniques to better understand the biology behind these behaviors, which could help create better support for those struggling with alcohol use.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | May 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $562,111 |
| NIH project number | 5R01AA030056-03 |
| Project ID | NIH-11012413 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals over 21 years old who have experienced issues related to alcohol consumption or alcohol use disorders.
✕Less likely to help
Patients who do not consume alcohol or have no history of alcohol-related issues may not benefit from this research.
What this research studies
This research investigates the genetic factors associated with alcohol consumption and alcohol use disorders (AUD) by analyzing data from genome-wide association studies (GWAS). The team will utilize advanced techniques, including mapping genetic variants to their potential effector genes using human stem cells and various neuronal models. By focusing on specific genetic markers and their effects on gene expression, the research aims to uncover the biological mechanisms underlying alcohol-related traits. This could lead to a better understanding of how genetics influence alcohol behavior and the development of targeted interventions.
Why it matters
Potential benefit: If successful, this research could lead to new genetic insights that inform prevention and treatment strategies for alcohol use disorders.
How similar studies have gone: Previous research using similar genetic mapping approaches has shown promise in identifying risk factors for various behavioral traits, suggesting potential for success in this area as well.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Kranzler, Henry Richard — University of Pennsylvania
- Study coordinator: Kranzler, Henry Richard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.