Identifying genes in the bacteria that cause dental cavities
Official title: Systematic Functional Genomics Analysis of the Oral Pathogen Streptococcus Mutans
Funded at Arkansas State University · NIH-11042588 · Data updated 2026-11-12
This study is looking at how certain genes in the bacteria that cause cavities help them stick together and form protective layers, which could lead to new ways to prevent and treat tooth decay.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arkansas State University NIH-funded |
| Lab location | 1 site (State University, United States) |
| Project start | September 24, 2024 |
| Project end | September 24, 2027 |
| Funding year | 2024 |
| Award (this year) | $419,161 |
| NIH project number | 1R15DE034550-01 |
| Project ID | NIH-11042588 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals, particularly children and adults, who are at risk for dental caries or have a history of dental decay.
✕Less likely to help
Patients who do not have issues related to dental health or are not at risk for dental caries may not benefit from this research.
What this research studies
This research focuses on understanding the genetic factors that contribute to the ability of the bacteria Streptococcus mutans to form biofilms, which are crucial for its role in causing dental caries. By creating a library of mutant strains of this bacterium, researchers will systematically identify which genes are important for its virulence. The study will utilize advanced sequencing techniques to analyze these mutants and their behavior in biofilms. This research aims to provide insights that could lead to new strategies for preventing and treating dental decay.
Why it matters
Potential benefit: If successful, this research could lead to innovative methods for reducing dental cavities and improving oral health.
How similar studies have gone: Previous research has successfully utilized genetic screening approaches to identify pathogenic determinants in other bacteria, suggesting that this methodology could yield valuable insights.
Where this research is happening
-
Arkansas State University
State University, United States Active
Researchers
- Principal investigator: Alam, Mohammad Abrar — Arkansas State University
- Study coordinator: Alam, Mohammad Abrar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.