Identifying genes and cell types that cause complex diseases
Integrative Approaches for Identifying Causal Gene-Cell Type Pairs of Complex Disease
This study is looking at how certain genes and types of cells are linked to complex diseases, helping us understand what causes these conditions so we can create better tests and treatments for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10901949 on NIH RePORTER |
What this research studies
This research focuses on uncovering the specific genes and cell types that contribute to complex diseases. By utilizing advanced techniques such as genome-wide association studies (GWAS), DNA sequencing, and RNA sequencing, the project aims to overcome limitations of traditional methods that often overlook the role of different cell types in disease. The approach integrates patient data with cell-type-specific information to pinpoint which genes are affected in particular cell types, thereby enhancing our understanding of disease mechanisms. This knowledge is crucial for developing targeted diagnostic and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with complex diseases who are willing to provide genetic and biological samples.
Not a fit: Patients with conditions that are not classified as complex diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more precise diagnostics and personalized treatment options for patients with complex diseases.
How similar studies have performed: Previous research has shown promise in identifying causal genes through similar integrative approaches, suggesting a strong potential for success in this area.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Huang, Kuan-Lin — Icahn School of Medicine at Mount Sinai
- Study coordinator: Huang, Kuan-Lin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.