Identifying gene markers for airway disease and COPD treatment response
Defining a gene expression signature of airway disease, COPD exacerbations, and response to treatment
This study is looking at how your genes might affect your COPD and how well you respond to treatments like inhaled steroids, so we can find better ways to personalize your care and help manage your symptoms more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11088732 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that influence chronic obstructive pulmonary disease (COPD) and how patients respond to treatments like inhaled corticosteroids. By analyzing blood samples from participants in a long-term study, researchers aim to identify specific gene expression patterns that correlate with disease severity and treatment outcomes. The goal is to develop predictive models that can help tailor treatments based on individual genetic profiles, potentially improving management of COPD exacerbations and progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with chronic obstructive pulmonary disease (COPD) who are experiencing exacerbations or are undergoing treatment.
Not a fit: Patients with mild respiratory issues or those without a COPD diagnosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment strategies for COPD patients, improving their health outcomes and quality of life.
How similar studies have performed: Previous research has shown promise in using genetic markers to predict treatment responses in other diseases, suggesting potential success for this approach in COPD.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Hersh, Craig P — Brigham and Women's Hospital
- Study coordinator: Hersh, Craig P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.