Identifying gene markers for airway disease and COPD treatment response
Official title: Defining a gene expression signature of airway disease, COPD exacerbations, and response to treatment
Funded at Brigham and Women's Hospital · NIH-11088732 · Data updated 2026-11-12
This study is looking at how your genes might affect your COPD and how well you respond to treatments like inhaled steroids, so we can find better ways to personalize your care and help manage your symptoms more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $832,016 |
| NIH project number | 5R01HL166231-03 |
| Project ID | NIH-11088732 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with chronic obstructive pulmonary disease (COPD) who are experiencing exacerbations or are undergoing treatment.
✕Less likely to help
Patients with mild respiratory issues or those without a COPD diagnosis may not benefit from this research.
What this research studies
This research investigates the genetic factors that influence chronic obstructive pulmonary disease (COPD) and how patients respond to treatments like inhaled corticosteroids. By analyzing blood samples from participants in a long-term study, researchers aim to identify specific gene expression patterns that correlate with disease severity and treatment outcomes. The goal is to develop predictive models that can help tailor treatments based on individual genetic profiles, potentially improving management of COPD exacerbations and progression.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment strategies for COPD patients, improving their health outcomes and quality of life.
How similar studies have gone: Previous research has shown promise in using genetic markers to predict treatment responses in other diseases, suggesting potential success for this approach in COPD.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Hersh, Craig P — Brigham and Women's Hospital
- Study coordinator: Hersh, Craig P
Related research
Other NIH-funded projects on the same topics.
-
Omalizumab for COPD patients with allergen sensitization and exposure
A multicenter trial will test whether adding omalizumab helps people with COPD who are allergic to common indoor allergens and are exposed to them.
-
Clinical CT Imaging to identify and subtype pulmonary hypertension in COPD
A new CT imaging approach aims to help doctors detect and classify pulmonary hypertension in people with COPD.
-
Next-Generation Wearable AI for Precision COPD Risk and Care
A patient-centered project uses a smart wearable and AI to predict COPD flare-ups and support doctors in making better care decisions.
-
Ethics-aware Multimodal AI for COPD prevention, diagnosis, and treatment
A broad AI model uses diverse health data to help predict and manage COPD in people, with an emphasis on ethics and fairness.
-
Easier, local pulmonary rehab and social support for people with COPD in low-resource clinics
This project compares a 10-week community pulmonary rehabilitation program alone, the same program plus help with social needs, and usual care for people with moderate-to-severe COPD to see which helps people stick with rehab and feel better.
-
Improving COPD outcomes with real-world data
A doctor-scientist at a major university is using real-world information from COPD patients to understand which treatments work best, how safe they are, and whether people stick to their inhaler plans.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.