Identifying gene elements to target specific brain cell types.
Systematic identification of enhancers to target the breadth of excitatory and inhibitory neuronal cell types in the cerebral cortex
This study is looking for ways to better understand and control specific brain cells to help develop new treatments for conditions like epilepsy and mental health issues, so that patients can have more effective therapies in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10512459 on NIH RePORTER |
What this research studies
This research focuses on discovering gene regulatory elements that allow for the precise targeting and manipulation of specific neuron populations in the human brain. By gaining genetic access to these neurons, researchers aim to modulate brain circuits, which could lead to new treatments for conditions like epilepsy and psychiatric disorders. The approach combines advanced techniques such as single-cell RNA sequencing and engineered viral vectors to explore brain circuitry and gene expression. Patients may benefit from the insights gained through this research, which could improve therapeutic strategies for neurological conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are adults aged 21 and older with epilepsy or psychiatric disorders.
Not a fit: Patients with conditions unrelated to brain circuitry or those under 21 years old may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies for epilepsy and psychiatric disorders, improving patient outcomes.
How similar studies have performed: Previous research has shown success in identifying gene regulatory elements for targeted gene expression, indicating a promising foundation for this approach.
Where this research is happening
Cambridge, United States
- Broad Institute, INC. — Cambridge, United States (Active)
Researchers
- Principal investigator: Fishell, Gordon J — Broad Institute, INC.
- Study coordinator: Fishell, Gordon J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.