Identifying factors that help stroke survivors respond to exercise training
Official title: What makes a responder, a responder? Biomarkers to help identify responders and resistors to high-intensity interval training for lower extremity chronic stroke
Funded at Veterans Health Administration · NIH-11030787 · Data updated 2026-11-12
This study is looking to find out which stroke survivors might get the most help from a special type of exercise called high-intensity interval training to walk better, using certain biological markers to create personalized exercise plans just for them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Decatur, UNITED STATES) |
| Project start | January 1, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| NIH project number | 5I01RX004537-02 |
| Project ID | NIH-11030787 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are chronic subcortical stroke survivors who experience difficulty walking and are over 21 years old.
✕Less likely to help
Patients who have not experienced a stroke or those with conditions that severely limit their ability to participate in exercise may not benefit from this research.
What this research studies
This research investigates how to predict which chronic stroke survivors will benefit from high-intensity interval training to improve their walking ability. By focusing on biomarkers like lactate and neurotransmitters, the study aims to develop a predictive model that can guide personalized exercise interventions. This approach seeks to enhance rehabilitation outcomes by tailoring exercise programs to individual patient needs based on their biological responses. The ultimate goal is to improve functional recovery in stroke patients through targeted aerobic exercise.
Why it matters
Potential benefit: If successful, this research could lead to more effective rehabilitation strategies for stroke survivors, enhancing their mobility and quality of life.
How similar studies have gone: Previous research has shown promise in using biomarkers to tailor rehabilitation strategies, suggesting that this approach could yield significant insights.
Where this research is happening
-
Veterans Health Administration
Decatur, United States Active
Researchers
- Principal investigator: Krishnamurthy, Lisa C. — Veterans Health Administration
- Study coordinator: Krishnamurthy, Lisa C.
Related research
Other NIH-funded projects on the same topics.
-
Non-Invasive Brain Stimulation to Improve Movement After Stroke
A new non-invasive technique called kilohertz Transcranial Magnetic Perturbation (kTMP) is being tested to improve arm movement in people who have chronic stroke.
-
Instrumented brain organoids for chronic stroke repair
A study exploring how tiny, living brain tissue 3D «organoids» attached to flexible, safer electrodes could help restore brain function after a stroke.
-
Multisensory support to improve standing balance after stroke
This project uses extra sensory feedback to help people with long-term stroke improve their standing balance.
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Biomarkers to predict who benefits from high‑intensity aerobic training after chronic stroke
This project looks at blood and brain signals to figure out who with long‑term leg weakness after stroke will get better with high‑intensity aerobic training.
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Improving hand function in stroke survivors with muscle activation techniques
This study is looking at how special techniques can help people who have had a moderate-to-severe stroke improve their hand use, making it easier for them to do everyday tasks and regain their independence.
-
Understanding balance control while walking in people with chronic stroke
This study looks at how people who have had a stroke keep their balance while walking in tricky situations, and it aims to find ways to help them improve their walking and balance during recovery.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.