Identifying factors linked to mild and severe COVID-19 infections
Project 1 - A systems biology approach to identify early networks and signatures associated with mild and severe SARS-CoV-2 infections in vivo
This study is looking at how different biological factors might explain why some people have mild COVID-19 while others get very sick, especially focusing on those with conditions like obesity and diabetes, to help find better ways to treat and manage the virus.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11005780 on NIH RePORTER |
What this research studies
This research investigates how different biological networks and signatures are associated with mild and severe cases of COVID-19. By analyzing clinical samples from patients and using animal models, the study aims to uncover key drivers and biomarkers that influence disease severity. The approach involves integrating various types of biological data (multi-OMICs) to better understand how pre-existing immunity and comorbidities like obesity and diabetes affect COVID-19 outcomes. This comprehensive analysis could lead to improved strategies for managing and treating COVID-19.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with COVID-19, particularly those with comorbidities such as obesity, advanced age, or type 2 diabetes.
Not a fit: Patients who are not infected with SARS-CoV-2 or do not have any associated comorbidities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better identification of patients at risk for severe COVID-19, allowing for targeted interventions and improved treatment outcomes.
How similar studies have performed: Other research has shown success in using multi-OMICs approaches to understand complex diseases, suggesting that this methodology could yield valuable insights for COVID-19.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Garcia-Sastre, Adolfo — Icahn School of Medicine at Mount Sinai
- Study coordinator: Garcia-Sastre, Adolfo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.