Identifying early tuberculosis and HIV infections in young children using blood tests
Mtb and HIV/SIV antigen peptide signatures as blood biomarkers to detect early infection to active disease in young children and NHP
This study is working on a new blood test to help doctors better diagnose tuberculosis and HIV in young children, making it easier to spot these illnesses early and track how well treatment is working.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-11070373 on NIH RePORTER |
What this research studies
This research focuses on developing blood biomarkers to improve the diagnosis of tuberculosis (TB) and HIV in young children. Current diagnostic methods often fail to detect TB in children, especially those co-infected with HIV, leading to severe health consequences. The study aims to create non-sputum-based tests that can accurately identify active TB and monitor treatment responses by detecting specific proteins in the blood. This approach is particularly crucial for young children who may present with non-specific symptoms and are at high risk of mortality.
Who could benefit from this research
Good fit: Ideal candidates for this research include young children under 11 years old who are at risk for TB and HIV infections.
Not a fit: Patients who are not children or those who do not have risk factors for TB or HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses of TB and HIV in young children, significantly improving treatment outcomes.
How similar studies have performed: Previous research has shown promise in using blood biomarkers for diagnosing TB and HIV, indicating that this approach may be effective.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: Lyon, Christopher J — Tulane University of Louisiana
- Study coordinator: Lyon, Christopher J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.