Identifying early signs of Parkinson's disease
Preclinical Markers of Parkinsonism
This study is looking for early signs of Parkinson's disease by examining people with a sleep condition called REM behavior disorder, hoping to find ways to spot mild symptoms before a diagnosis, which could help in starting treatments sooner for those at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10876354 on NIH RePORTER |
What this research studies
This research aims to discover early markers of Parkinson's disease by studying a condition known as rapid eye movement (REM) behavior disorder, which often precedes Parkinson's. By combining insights from neurology, motor control, neuroimaging, and biomarkers, the researchers hope to identify Mild Parkinson Impairment (MPI) before a formal diagnosis is made. This approach could lead to earlier interventions and potentially disease-modifying therapies for those at risk. The study will utilize innovative imaging and physiological markers to track changes in patients over time.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with rapid eye movement (REM) behavior disorder.
Not a fit: Patients who do not have REM behavior disorder or other related synucleinopathies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and treatment options for individuals at risk of developing Parkinson's disease.
How similar studies have performed: Previous research has successfully identified early markers in Alzheimer's disease, suggesting that similar approaches may be effective for Parkinson's disease.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Vaillancourt, David E — University of Florida
- Study coordinator: Vaillancourt, David E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.