Identifying early signs of liver cancer using exosomal biomarkers
Official title: Exosomal biomarkers for the early detection of hepatocellular carcinoma
Funded at Beckman Research Institute/city of Hope · NIH-10902031 · Data updated 2026-11-12
This study is looking for new ways to spot liver cancer early by testing tiny molecules in the blood, which could help people with chronic liver issues get better treatment sooner.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | August 8, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $693,134 |
| NIH project number | 5R01CA271443-02 |
| Project ID | NIH-10902031 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with chronic hepatitis, liver cirrhosis, or other risk factors for hepatocellular carcinoma.
✕Less likely to help
Patients without risk factors for liver cancer or those with advanced-stage liver cancer may not benefit from this research.
What this research studies
This research focuses on developing new biomarkers to detect hepatocellular carcinoma (HCC) at an early stage, which is crucial for improving treatment outcomes. The study will analyze exosomal microRNAs, which are small molecules that can indicate the presence of cancer even before symptoms appear. By utilizing advanced bioinformatics and biological assays, the research aims to enhance the sensitivity and specificity of current detection methods, such as alpha-fetoprotein testing and ultrasound imaging. Patients at high risk for liver cancer, particularly those with chronic liver conditions, may benefit from these innovative detection strategies.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate detection of liver cancer, significantly improving survival rates.
How similar studies have gone: Previous research has shown promise in using microRNAs as biomarkers for various cancers, indicating a potential for success in this novel approach.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Goel, Ajay — Beckman Research Institute/city of Hope
- Study coordinator: Goel, Ajay
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.