Identifying early signs of depression in at-risk teenagers
Predicting the onset of depression in at-risk adolescents from endophenotype profiles
This study is looking at how certain brain and behavior traits can help us understand if teens aged 12-15, who have family members with depression, might be at risk for developing major depression themselves, so we can find ways to help them early on.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mclean Hospital NIH-funded |
| Lab location | 1 site (Belmont, United States) |
| Project ID | NIH-10517503 on NIH RePORTER |
What this research studies
This research investigates how certain brain and behavioral traits can help predict the onset of major depressive disorder (MDD) in adolescents aged 12-15 who have a family history of depression. By using advanced imaging techniques like fMRI and behavioral assessments, the study aims to identify specific endophenotypes—traits that indicate a higher risk for developing depression. The goal is to enhance early detection and intervention strategies for at-risk youth, potentially leading to better mental health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adolescents aged 12-15 who have a parent with a history of major depressive disorder.
Not a fit: Patients who do not have a family history of depression or are outside the age range of 12-15 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier identification and targeted interventions for adolescents at risk of developing depression.
How similar studies have performed: Previous research has shown promise in identifying risk factors for depression using similar neurobiological and behavioral approaches, suggesting this study builds on established findings.
Where this research is happening
Belmont, United States
- Mclean Hospital — Belmont, United States (Active)
Researchers
- Principal investigator: Webb, Christian Anthony — Mclean Hospital
- Study coordinator: Webb, Christian Anthony
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.