Identifying early signs of Alzheimer's disease using non-invasive tests
Official title: Cognitive challenge to reveal systemic neurophysiology biomarkers in pre-symptomatic Alzheimer’s disease
Funded at Huntington Medical Research Institutes · NIH-11031394 · Data updated 2026-11-12
This study is looking for easy ways to spot early signs of Alzheimer's disease in older adults before any symptoms show up, using fun brain games and special tests to see how their brains are working.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Huntington Medical Research Institutes NIH-funded |
| Lab location | 1 site (Pasadena, UNITED STATES) |
| Project start | May 15, 2021 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $791,592 |
| NIH project number | 5R01AG063857-05 |
| Project ID | NIH-11031394 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are elderly individuals who are cognitively healthy but may be at risk for Alzheimer's disease based on specific biomarkers.
✕Less likely to help
Patients who are already diagnosed with Alzheimer's disease or those with significant cognitive impairment may not benefit from this research.
What this research studies
This research aims to find non-invasive biomarkers for early detection of Alzheimer's disease (AD) before symptoms appear. By using a combination of cognitive challenges and advanced neurophysiological measurements, the study will classify elderly participants into groups based on their risk of developing AD. The goal is to develop simple tests that can predict cognitive decline, potentially allowing for earlier intervention and management of the disease. Participants will undergo assessments that measure brain activity and other physiological responses to understand the underlying changes associated with AD.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accessible detection of Alzheimer's disease, improving patient outcomes through timely intervention.
How similar studies have gone: Previous research has shown promise in using non-invasive methods to detect early signs of Alzheimer's disease, indicating that this approach could be effective.
Where this research is happening
-
Huntington Medical Research Institutes
Pasadena, United States Active
Researchers
- Principal investigator: Arakaki, Xianghong — Huntington Medical Research Institutes
- Study coordinator: Arakaki, Xianghong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.