Identifying early signs of Alzheimer's disease using brain imaging and cognitive tests
Developing novel cognitive and neuroimaging markers of early Alzheimers disease pathologies
This study is looking for early signs of Alzheimer's in older adults who seem healthy by using brain scans and memory tests, so we can better understand and treat the disease before it gets worse.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-10879027 on NIH RePORTER |
What this research studies
This research aims to discover new cognitive and neuroimaging markers that can detect early changes in the brain associated with Alzheimer's disease, particularly in older adults who appear clinically healthy. By utilizing advanced imaging techniques like positron emission tomography (PET), the study will examine the presence of beta-amyloid plaques and tau-protein tangles, which are key indicators of Alzheimer's pathology. Participants will undergo a series of cognitive tests and brain scans to help differentiate between healthy aging and early signs of Alzheimer's. The goal is to improve early diagnosis and treatment monitoring for individuals at risk of developing Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include cognitively normal older adults and healthy young adults.
Not a fit: Patients with diagnosed Alzheimer's disease or significant cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnosis of Alzheimer's disease, allowing for timely interventions.
How similar studies have performed: Other research has shown promise in using neuroimaging and cognitive assessments to identify early Alzheimer's pathology, indicating that this approach has potential for success.
Where this research is happening
Providence, United States
- Brown University — Providence, United States (Active)
Researchers
- Principal investigator: Oh, Hwamee — Brown University
- Study coordinator: Oh, Hwamee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.