Identifying early life factors that lead to Alzheimer's Disease
Project 1: Identification of Early Life molecular determinants of Alzheimer's Disease pathogenesis
This study is looking at how certain changes in the brain from birth to young adulthood can lead to Alzheimer's Disease, using specially modified marmosets, to help find ways to prevent the disease before it starts.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10899741 on NIH RePORTER |
What this research studies
This research investigates the early life molecular and cellular events that contribute to the development of Alzheimer's Disease (AD). By studying genetically engineered marmosets with a specific mutation linked to early-onset AD, researchers aim to uncover the biological mechanisms that initiate and progress the disease. The study focuses on observing these changes from birth through various life stages, including infancy and adolescence, to better understand how AD can be prevented. The findings could lead to new strategies for early intervention in at-risk populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of Alzheimer's Disease or those identified as having genetic risk factors for the condition.
Not a fit: Patients who are already diagnosed with Alzheimer's Disease or those without any genetic predisposition to the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new prevention strategies for Alzheimer's Disease, potentially reducing its incidence in future generations.
How similar studies have performed: Other research has shown promise in understanding early life determinants of Alzheimer's Disease, but this specific approach using genetically engineered marmosets is relatively novel.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Rizzo, Stacey J — University of Pittsburgh at Pittsburgh
- Study coordinator: Rizzo, Stacey J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.