Identifying early brain changes linked to Alzheimer's disease
Quantification of microstructures in the entorhinal-hippocampus pathway as a sensitive biomarker for neurodegeneration during the preclinical stage of Alzheimer's disease
This study is looking at tiny changes in the brain that could show early signs of Alzheimer's disease, helping us find ways to spot the condition before symptoms start, so we can take action sooner.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10949187 on NIH RePORTER |
What this research studies
This research investigates the early microstructural changes in the entorhinal-hippocampus pathway to identify sensitive biomarkers for neurodegeneration associated with Alzheimer's disease. By focusing on the preclinical stage of the disease, the study aims to develop tools that can predict cognitive decline before symptoms appear. The approach involves advanced neuroimaging techniques to detect subtle changes in brain structure that may indicate the onset of Alzheimer's. This could lead to earlier interventions and better management of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Alzheimer's disease, particularly those in the preclinical stage without noticeable cognitive impairment.
Not a fit: Patients who are already experiencing significant cognitive decline or have a confirmed diagnosis of Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enable earlier diagnosis and intervention for Alzheimer's disease, potentially slowing its progression.
How similar studies have performed: Previous research has shown promise in identifying biomarkers for Alzheimer's disease, but this specific approach focusing on the entorhinal-hippocampus pathway is relatively novel.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Uchida, Yuto — Johns Hopkins University
- Study coordinator: Uchida, Yuto
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.