Identifying drug resistance in multiple myeloma to improve treatment options
Characterize Drug Resistance in Multiple Myeloma
This study is looking for special markers in tough multiple myeloma cells that don't respond to treatment, so we can create better therapies to help patients avoid relapse and improve their chances of recovery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Central Arkansas Veterans Hlthcare Sys NIH-funded |
| Lab location | 1 site (North Little Rock, United States) |
| Project ID | NIH-10925595 on NIH RePORTER |
What this research studies
This research aims to identify specific biomarkers associated with drug-resistant multiple myeloma (MM) cells. By analyzing the molecular signatures and regulatory elements of these cells, the researchers hope to develop new therapies that can effectively target and eliminate drug-resistant cells, thereby preventing relapse. The study utilizes advanced techniques such as single-cell multi-omics profiling and CAR-T cell therapy to enhance treatment efficacy. Patients may benefit from innovative treatment strategies tailored to their unique cancer profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with multiple myeloma, particularly those who have experienced treatment resistance.
Not a fit: Patients with early-stage multiple myeloma who have not yet undergone treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies that prevent relapse in multiple myeloma patients.
How similar studies have performed: Previous research has shown promise in using CAR-T cell therapy for treating multiple myeloma, indicating potential success for this approach.
Where this research is happening
North Little Rock, United States
- Central Arkansas Veterans Hlthcare Sys — North Little Rock, United States (Active)
Researchers
- Principal investigator: Zhan, Fenghuang — Central Arkansas Veterans Hlthcare Sys
- Study coordinator: Zhan, Fenghuang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.