Identifying DNA markers to predict Alzheimer's disease and cognitive decline
New DNA methylation biomarkers for predicting AD and cognitive decline
This study is looking for ways to use DNA markers to help predict who might be at risk for Alzheimer's disease and memory problems, so if you join, you could help create tools that make it easier to spot those at risk and find better ways to prevent dementia.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11059162 on NIH RePORTER |
What this research studies
This research focuses on developing new DNA methylation biomarkers that can help predict the risk of Alzheimer's disease (AD) and cognitive decline. By analyzing large clinical datasets, the researchers aim to create models that can accurately identify individuals at risk for AD in a non-invasive and cost-effective manner. The study will also explore how cognitive reserve influences these biomarkers, potentially leading to personalized treatment strategies and lifestyle interventions for dementia prevention. Patients participating in this research may contribute to the creation of tools that enhance our understanding of AD and improve clinical trial selection.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are at risk for Alzheimer's disease or those experiencing early signs of cognitive decline.
Not a fit: Patients with established Alzheimer's disease or severe cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate identification of individuals at risk for Alzheimer's disease, enabling timely interventions.
How similar studies have performed: Previous research has shown promise in using DNA methylation markers for predicting various health conditions, suggesting that this approach may yield valuable insights for Alzheimer's disease as well.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Wang, Lily — University of Miami School of Medicine
- Study coordinator: Wang, Lily
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.