Identifying DNA markers related to multiple chronic diseases in older adults
DNA methylation markers of Multimorbidity in Aging Humans and Mice
This study is looking at how certain changes in our DNA might help us understand why some older adults have multiple chronic diseases, with the hope of finding ways to spot those at risk so they can get help sooner.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10601113 on NIH RePORTER |
What this research studies
This research investigates the relationship between DNA methylation markers and multimorbidity, which refers to the presence of multiple chronic diseases in older adults. By analyzing both human populations and mouse models, the study aims to identify specific DNA markers that can predict the likelihood of developing multimorbidity. The approach involves measuring DNA methylation and gene expression to understand how these biological factors differ between individuals with and without chronic diseases. The ultimate goal is to create tools that can help identify at-risk individuals, improving early intervention and management strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are experiencing or are at risk of developing multiple chronic diseases.
Not a fit: Patients who are younger or do not have any chronic diseases may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prediction and management of chronic diseases in older adults, potentially improving their quality of life.
How similar studies have performed: Previous research has shown promise in identifying biomarkers for chronic diseases, but this approach focusing on DNA methylation in the context of multimorbidity is relatively novel.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Salimi, Shabnam — University of Washington
- Study coordinator: Salimi, Shabnam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.