Identifying disease-causing genes using advanced statistical methods
Official title: DMS/NIGMS 1: Disease gene discovery by Markovian gene network
Funded at Rutgers, the State Univ of N.j. · NIH-11043520 · Data updated 2026-11-12
This study is looking at how genes work together to help us understand the causes of complex diseases, using patients' genetic information to find specific gene changes that could lead to better diagnoses and treatments for those conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project start | September 10, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $179,703 |
| NIH project number | 1R01GM157610-01 |
| Project ID | NIH-11043520 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with complex diseases that may have a genetic component.
✕Less likely to help
Patients with purely environmental or non-genetic conditions may not benefit from this research.
What this research studies
This research focuses on developing new statistical methods to better understand the genetic basis of complex diseases. By analyzing how genes interact within networks, the project aims to identify mutations that cause diseases. The approach involves modeling gene interactions as a Markovian network, which allows researchers to track how these interactions evolve over time. Patients' genetic data will be utilized to pinpoint candidate genes linked to specific disorders, potentially leading to more accurate diagnoses and treatments.
Why it matters
Potential benefit: If successful, this research could lead to the discovery of new disease-causing genes, improving diagnosis and treatment options for patients with complex genetic disorders.
How similar studies have gone: Previous research has shown promise in using network models to identify disease genes, indicating that this approach could yield significant insights.
Where this research is happening
-
Rutgers, the State Univ of N.j.
Piscataway, United States Active
Researchers
- Principal investigator: Xu, Min — Rutgers, the State Univ of N.j.
- Study coordinator: Xu, Min
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.