Identifying different types of Type 2 diabetes in diverse populations
Official title: GEneration and assessment of Multi-omic informed Subtypes of Type 2 Diabetes in Diverse Populations (GEMS-T2D)
Funded at Massachusetts General Hospital · NIH-10974663 · Data updated 2026-11-12
This study is working on a new way to understand different types of Type 2 diabetes by looking at both health history and genetics, so that doctors can create more personalized treatment plans to help you manage your diabetes better.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $784,636 |
| NIH project number | 1U01DK140757-01 |
| Project ID | NIH-10974663 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Type 2 diabetes, particularly those from diverse backgrounds and varying clinical profiles.
✕Less likely to help
Patients who do not have Type 2 diabetes or those with other forms of diabetes may not benefit from this research.
What this research studies
This research aims to develop a new classification system for Type 2 diabetes (T2D) that takes into account various clinical and genetic factors. By analyzing a large and diverse set of patient data, including genetic information and clinical histories, the study seeks to create a more accurate understanding of T2D subtypes. This approach will help in personalizing treatment plans for individuals based on their specific diabetes subtype, potentially leading to better management of the disease over time.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment strategies for individuals with Type 2 diabetes.
How similar studies have gone: Previous research has shown promise in identifying diabetes subtypes, but this approach aims to standardize and improve upon those methods, making it a novel effort.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Udler, Miriam Sargon — Massachusetts General Hospital
- Study coordinator: Udler, Miriam Sargon
Related research
Other NIH-funded projects on the same topics.
-
Subtyping Core for Research on the Causes of Type 2 Diabetes (SCORE-T2D)
A new U01 grant from a university research team aims to understand why Type 2 diabetes differs so much between people and how to tailor prevention and treatment.
-
Michigan Diabetes Project: A Peer-Led Self-Management Program for Adults with Type 2 Diabetes
A peer-led self-management program for adults with type 2 diabetes is being tested to see if it improves blood sugar control and daily diabetes care.
-
Alzheimer’s and dementia risk in people with prediabetes or type 2 diabetes
This grant aims to understand why some older adults with prediabetes or type 2 diabetes develop memory problems or dementia.
-
Personalized use of newer diabetes medicines for Type 2 diabetes
Aiming to tailor use of newer glucose-lowering drugs for people with type 2 diabetes to improve health and access in real-world settings.
-
Alzheimer’s and related dementia in older adults with prediabetes or type 2 diabetes
This grant aims to understand why cognitive problems occur in people 65 and older who have prediabetes or type 2 diabetes, using data from a long-running diabetes study to identify what drives memory and thinking decline.
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Understanding why youth develop type 2 diabetes and how to prevent it
A nationwide study aims to unravel why some teens with obesity develop type 2 diabetes while others don’t, and to identify factors that could help prevent it.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.