Identifying different types of severe respiratory distress in children and how they respond to treatment
ENdotypes in Children with Severe Acute Respiratory Distress SyNdrome: ImpAct on REsponse to Treatment (ENSNARE)
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10532690
This study is looking at how severe breathing problems in kids, known as ARDS, can be different for each child, and by examining their blood, researchers hope to find better ways to treat them based on their unique needs.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10532690 on ClinicalTrials.gov |
What this research studies
This research investigates severe acute respiratory distress syndrome (ARDS) in children, aiming to identify distinct subtypes or endotypes that may influence treatment responses. By analyzing gene expression in blood samples from pediatric patients, the study seeks to uncover variations in the underlying biology of ARDS. This approach could lead to more personalized treatment strategies based on the specific endotype of each child. The research builds on previous findings in adult populations and aims to fill a critical gap in understanding pediatric ARDS.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with severe acute respiratory distress syndrome.
Not a fit: Patients with mild respiratory issues or those not diagnosed with ARDS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for children suffering from severe respiratory distress, potentially reducing mortality and morbidity.
How similar studies have performed: Previous research in adult populations has successfully identified ARDS endotypes, suggesting that this approach may also yield valuable insights in pediatric cases.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DAHMER, MARY K — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: DAHMER, MARY K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.