Identifying different types of sepsis in Uganda based on patient data and immune responses
Subtyping sepsis in Uganda using clinical, pathogen, and host response profiling
['FUNDING_OTHER'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-11009064
This study is looking at different types of sepsis in Uganda, especially in people with HIV, to better understand how to treat these infections based on local needs.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11009064 on ClinicalTrials.gov |
What this research studies
This research investigates the various forms of sepsis that occur in Uganda, particularly in patients with HIV. By analyzing clinical data, pathogen information, and host responses, the study aims to create specific subtypes of sepsis that reflect the unique challenges faced in sub-Saharan Africa. The approach includes using advanced techniques like machine learning and RNA sequencing to better understand how different biological factors contribute to severe infections. This work is crucial for developing effective treatment strategies tailored to the local context.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults living in Uganda who are experiencing sepsis, particularly those with HIV.
Not a fit: Patients outside of Uganda or those without sepsis or HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment protocols for sepsis in HIV-infected patients in Uganda.
How similar studies have performed: Previous research has shown that localized approaches to understanding sepsis can lead to significant improvements in treatment outcomes, suggesting this study's approach is promising.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CUMMINGS, MATTHEW JOHN — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: CUMMINGS, MATTHEW JOHN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus