Identifying different types of Parkinson's disease using patient-derived neurons
Molecular Segregation of Parkinson’s Disease by Patient-Derived Neurons
['FUNDING_R01'] · STATE UNIVERSITY OF NEW YORK AT BUFFALO · NIH-10843294
This study is looking at how Parkinson's disease can be grouped based on whether people have tremors when they first start showing symptoms, and it aims to find unique biological markers that can help tell the difference between healthy people and those with Parkinson's, using advanced techniques to better understand the disease and improve how we diagnose and treat it.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY OF NEW YORK AT BUFFALO (nih funded) |
| Locations | 1 site (AMHERST, UNITED STATES) |
| Trial ID | NIH-10843294 on ClinicalTrials.gov |
What this research studies
This research investigates how Parkinson's disease (PD) can be categorized based on the presence of rest tremor at onset and aims to identify molecular signatures that differentiate PD patients from healthy individuals. By utilizing innovative technologies, such as converting skin and urinary cells into midbrain neurons, the study examines gene expression differences in these neurons from both normal subjects and PD patients. The goal is to enhance the understanding of PD and improve diagnostic methods, which could lead to more personalized treatment approaches for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Parkinson's disease, particularly those with varying symptoms related to rest tremor.
Not a fit: Patients with Parkinson's disease who do not have access to the necessary biological samples or those with atypical forms of the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic techniques and tailored treatments for Parkinson's disease patients.
How similar studies have performed: Other research has shown promise in using patient-derived cells to study neurological diseases, indicating that this approach has potential for success.
Where this research is happening
AMHERST, UNITED STATES
- STATE UNIVERSITY OF NEW YORK AT BUFFALO — AMHERST, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FENG, JIAN — STATE UNIVERSITY OF NEW YORK AT BUFFALO
- Study coordinator: FENG, JIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.