Identifying different types of COPD using genetic and metabolic information
Official title: Identifying Subtypes of COPD Using Metabolomic and Genomic Approaches
Funded at Brigham and Women's Hospital · NIH-11087514 · Data updated 2026-11-12
This study is looking at how genes and metabolism affect chronic obstructive pulmonary disease (COPD) to find different types of the condition, and it’s inviting patients to help by sharing blood and lung samples for better diagnosis and treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 10, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $627,879 |
| NIH project number | 5R01HL168199-02 |
| Project ID | NIH-11087514 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic obstructive pulmonary disease (COPD), particularly those with varying disease presentations.
✕Less likely to help
Patients without a diagnosis of COPD or those with other unrelated respiratory conditions may not benefit from this research.
What this research studies
This research investigates chronic obstructive pulmonary disease (COPD) by exploring its genetic and metabolic underpinnings. It aims to identify distinct subtypes of COPD through an integrative approach that combines genetic data with metabolomic, transcriptomic, and proteomic analyses. By studying a cohort of 1,000 subjects, the research will analyze how genetic variants influence disease characteristics and identify potential biomarkers for better diagnosis and treatment. Patients may be asked to provide blood and lung samples for comprehensive analysis.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatments for COPD patients based on their specific disease subtype.
How similar studies have gone: Previous research has shown promise in using genetic and metabolic profiling to understand complex diseases, suggesting that this approach could yield valuable insights for COPD as well.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Cho, Michael H. — Brigham and Women's Hospital
- Study coordinator: Cho, Michael H.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.