Identifying Clues for Alzheimer's Disease in Older Adults
Biomarker Core
['FUNDING_OTHER'] · MAYO CLINIC JACKSONVILLE · NIH-11105808
This project aims to find early signs of Alzheimer's disease and age-related memory changes by looking at specific markers in blood and spinal fluid from older adults.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC JACKSONVILLE (nih funded) |
| Locations | 1 site (JACKSONVILLE, UNITED STATES) |
| Trial ID | NIH-11105808 on ClinicalTrials.gov |
What this research studies
This project focuses on finding biological markers in blood and spinal fluid that could indicate Alzheimer's disease or age-related memory decline. Researchers are particularly interested in how a gene called APOE affects these markers and how it relates to changes in thinking abilities over time. They will study samples collected over 2-3 years from older adults, specifically looking at how their memory and thinking skills change. This work uses existing samples from large groups of people at Mayo Clinic and Washington University, aiming to connect these biological clues with actual changes in brain health.
Who could benefit from this research
Good fit: This project primarily uses existing biospecimens from individuals aged 65 and older who have participated in previous studies at Mayo Clinic and Washington University.
Not a fit: Patients not enrolled in the specific Mayo Clinic Study of Aging or Alzheimer's Disease Research Centers at Mayo Clinic or Washington University would not directly participate in this particular project.
Why it matters
Potential benefit: If successful, this work could lead to earlier and more accurate ways to detect Alzheimer's disease and predict cognitive decline.
How similar studies have performed: Research into APOE and its role in Alzheimer's disease biomarkers is ongoing, with many studies contributing to our understanding of these complex relationships.
Where this research is happening
JACKSONVILLE, UNITED STATES
- MAYO CLINIC JACKSONVILLE — JACKSONVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KANEKIYO, TAKAHISA — MAYO CLINIC JACKSONVILLE
- Study coordinator: KANEKIYO, TAKAHISA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.