Identifying cancer risk in patients with Barrett's esophagus using a new test
Official title: Stratification of Cancer Risk in Patients with Non-Dysplastic Barrett's Esophagus using TissueCypher: The SCRiBE study
Funded at Baylor Research Institute · NIH-11114067 · Data updated 2026-11-12
This study is looking at how to better spot patients with Barrett's esophagus who might be at risk for developing esophageal cancer, using a special test on biopsy samples to find early signs of trouble, so we can help manage their health more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor Research Institute NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $577,120 |
| NIH project number | 5R01DK131951-03 |
| Project ID | NIH-11114067 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Barrett's esophagus, particularly those who have a history of gastroesophageal reflux disease.
✕Less likely to help
Patients who do not have Barrett's esophagus or those with other unrelated esophageal conditions may not benefit from this research.
What this research studies
This research focuses on Barrett's esophagus, a condition that can lead to esophageal cancer, and aims to improve how we identify patients at risk for developing this cancer. The study utilizes the TissueCypher BE Assay, which analyzes biopsy samples to detect early molecular changes that indicate a higher risk of cancer, even in patients without dysplasia. By refining the screening process, the research seeks to provide a more effective way to monitor and manage Barrett's esophagus patients, potentially leading to better outcomes. Patients will be evaluated through endoscopic procedures and their biopsy results will inform their risk level for cancer progression.
Why it matters
Potential benefit: If successful, this research could lead to more accurate risk assessments for patients with Barrett's esophagus, allowing for timely interventions and potentially reducing the incidence of esophageal cancer.
How similar studies have gone: Previous studies have shown that similar approaches using the TissueCypher assay have successfully identified patients at varying risk levels for cancer progression.
Where this research is happening
-
Baylor Research Institute
Dallas, United States Active
Researchers
- Principal investigator: Souza, Rhonda F — Baylor Research Institute
- Study coordinator: Souza, Rhonda F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.