Identifying cancer gene variations that affect treatment response
Official title: Computational and functional discovery of isoforms driving cancer and drug resistance
Funded at University of California Santa Cruz · NIH-11035221 · Data updated 2026-11-12
This study is looking at how certain changes in cancer genes might affect tumor growth and how well treatments work, with the goal of helping doctors create more personalized treatment plans for cancer patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Cruz NIH-funded |
| Lab location | 1 site (Santa Cruz, United States) |
| Project start | February 14, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $684,945 |
| NIH project number | 5R01CA284585-02 |
| Project ID | NIH-11035221 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients with various types of cancer who are undergoing treatment and may have specific gene variations affecting their response.
✕Less likely to help
Patients with non-cancerous conditions or those whose cancer is not driven by genetic mutations may not benefit from this research.
What this research studies
This research investigates how specific variations in cancer genes, particularly those affecting RNA processing, contribute to tumor growth and resistance to therapies. By analyzing cancer cell lines and patient samples, the study aims to create a detailed catalog of gene isoforms that may influence treatment outcomes. The researchers will utilize advanced sequencing techniques and functional assays to understand how these variations impact cancer progression and response to targeted therapies. This approach seeks to enhance personalized treatment strategies for cancer patients.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized cancer treatments by identifying which gene variations are driving tumor growth and resistance.
How similar studies have gone: Previous research has shown promise in identifying gene variations related to cancer treatment responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California Santa Cruz
Santa Cruz, United States Active
Researchers
- Principal investigator: Brooks, Angela Norie — University of California Santa Cruz
- Study coordinator: Brooks, Angela Norie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.