Identifying cancer biomarkers through glycan analysis
Official title: Translating glycans into biomarkers
Funded at Medical University of South Carolina · NIH-10979400 · Data updated 2026-11-12
This study is exploring a new way to use changes in sugars found in the blood to help diagnose and track cancer and other diseases, using a quick and easy method called GlycoTyper that could make it easier for doctors to monitor patients' health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $596,254 |
| NIH project number | 1R01CA285370-01A1 |
| Project ID | NIH-10979400 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with liver disease or those at risk for developing cancers associated with glycosylation changes.
✕Less likely to help
Patients with conditions unrelated to glycosylation changes or those not diagnosed with cancer or liver disease may not benefit from this research.
What this research studies
This research focuses on understanding how changes in glycosylation, which are linked to various cancers and diseases, can be used as biomarkers for diagnosis and monitoring. The team has developed a new method called GlycoTyper that allows for quick and efficient profiling of N-glycans from serum samples without the need for extensive sample preparation. By using a combination of antibody arrays and mass spectrometry, this approach can analyze small amounts of serum and provide valuable information about disease progression. The goal is to validate these biomarkers in collaboration with clinical and industry partners to enhance their application in patient care.
Why it matters
Potential benefit: If successful, this research could lead to faster and more accurate cancer diagnoses and monitoring through the use of glycan biomarkers.
How similar studies have gone: Previous research has shown promise in using glycan profiling for biomarker discovery, indicating that this approach could be a significant advancement in the field.
Where this research is happening
-
Medical University of South Carolina
Charleston, United States Active
Researchers
- Principal investigator: Mehta, Anand S. — Medical University of South Carolina
- Study coordinator: Mehta, Anand S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.