Identifying brain regions that generate seizures using advanced EEG analysis
Quantitative interictal networks to localize seizure generators
This study is looking at ways to find the exact parts of the brain that cause seizures in people with epilepsy who don't respond to medication, so that doctors can plan surgeries that might help them feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10989933 on NIH RePORTER |
What this research studies
This research investigates how to better locate the areas of the brain responsible for seizures in patients with drug-resistant epilepsy. By analyzing interictal EEG data—brain activity recorded between seizures—researchers aim to identify specific brain regions, known as hubs, that may indicate where seizures originate. The study employs quantitative methods to evaluate interictal epileptiform discharges and functional connectivity, which could improve surgical planning for epilepsy treatment. Patients may benefit from a more accurate identification of seizure generators, potentially leading to better surgical outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with drug-resistant epilepsy who are considering surgical options for seizure management.
Not a fit: Patients with well-controlled epilepsy or those who do not meet the criteria for surgical intervention may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved surgical outcomes for patients with drug-resistant epilepsy by providing more accurate localization of seizure generators.
How similar studies have performed: Previous research has shown promise in using quantitative EEG analysis to improve seizure localization, suggesting that this approach may yield beneficial results.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Conrad, Erin — University of Pennsylvania
- Study coordinator: Conrad, Erin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.