Identifying brain regions causing seizures in children during anesthesia.
Official title: Intraoperative Localization of Epileptic Brain Regions Under Sevoflurane Anesthesia.
Funded at Wayne State University · NIH-10923816 · Data updated 2026-11-12
This study is looking at new ways to find the parts of the brain that cause seizures in children with hard-to-treat epilepsy, using special techniques during surgery to help doctors plan safer and more effective treatments.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | July 10, 2023 |
| Project end | July 9, 2025 |
| Funding year | 2024 |
| Award (this year) | $53,974 |
| NIH project number | 5F30NS129239-02 |
| Project ID | NIH-10923816 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who have drug-resistant focal epilepsy.
✕Less likely to help
Patients with epilepsy that is well-controlled by medication or those outside the age range may not benefit from this research.
What this research studies
This research focuses on improving the identification of brain regions responsible for drug-resistant epilepsy in children by using intraoperative techniques during sevoflurane anesthesia. The study aims to measure specific brain activity patterns, known as biomarkers, that indicate seizure activity, which can help guide surgical interventions. By utilizing advanced methods like intracranial electroencephalography (iEEG) and analyzing brain connectivity, the research seeks to enhance the accuracy and safety of epilepsy surgeries, reducing the need for prolonged pre-surgical monitoring. This approach could lead to more effective treatments for children suffering from epilepsy.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective surgical treatments for children with drug-resistant epilepsy.
How similar studies have gone: Previous research has shown promise in using intraoperative techniques for identifying seizure foci, suggesting that this approach could be a significant advancement in epilepsy treatment.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Firestone, Ethan Joseph — Wayne State University
- Study coordinator: Firestone, Ethan Joseph
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.