Identifying brain networks related to Alzheimer's disease
Connectomic Biomarkers of Preclinical Alzheimer's Disease within Multi-Synaptic Pathways
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11026499
This study is looking at how different parts of the brain change as we age and how they might be affected by Alzheimer's disease, with the goal of finding better ways to diagnose and understand the early stages of the disease, so that we can improve treatment and care for people experiencing memory problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11026499 on ClinicalTrials.gov |
What this research studies
This research aims to identify specific brain networks that are either vulnerable or resilient to aging and Alzheimer's disease (AD). By using advanced imaging techniques like diffusion-weighted MRI and resting-state functional MRI, the study seeks to create accurate biomarkers that can help in diagnosing and staging preclinical AD. The focus is on understanding how information flows through the brain's complex networks, which could lead to better predictions of disease progression and treatment efficacy. This approach may enhance our understanding of cognitive dysfunction associated with mild cognitive impairment and AD.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults who may be experiencing early signs of cognitive decline or are at risk for Alzheimer's disease.
Not a fit: Patients with advanced Alzheimer's disease or those with other forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatments for Alzheimer's disease, potentially delaying its onset.
How similar studies have performed: Previous research has shown promise in using connectomic approaches to understand cognitive dysfunction, indicating that this methodology could yield significant insights.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AGANJ, IMAN — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: AGANJ, IMAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia