Identifying brain injury risks in patients with aneurysmal subarachnoid hemorrhage using brain activity monitoring.
Official title: Electroencephalographic signatures of dysfunctional cerebrovascular autoregulation as biomarkers of brain injury in aneurysmal subarachnoid hemorrhage (SAH)
Funded at Yale University · NIH-10821463 · Data updated 2026-11-12
This study is looking at how to better manage blood pressure for people who have had a brain bleed from an aneurysm, by closely monitoring their brain activity to find the best targets for blood flow, which could help prevent further complications and improve recovery.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | April 15, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $209,375 |
| NIH project number | 5R21NS128641-02 |
| Project ID | NIH-10821463 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have suffered from an aneurysmal subarachnoid hemorrhage.
✕Less likely to help
Patients who are younger than 21 years old or those who have not experienced an aneurysmal subarachnoid hemorrhage may not benefit from this research.
What this research studies
This research investigates how abnormalities in blood flow regulation in the brain can lead to further injury in patients who have experienced an aneurysmal subarachnoid hemorrhage (aSAH). By continuously monitoring brain activity through EEG, intracranial pressure, and near-infrared spectroscopy, the study aims to personalize blood pressure management for these patients. The goal is to identify specific blood pressure targets that optimize brain blood flow and metabolism, potentially reducing the risk of complications like delayed cerebral ischemia. This innovative approach seeks to improve patient outcomes by tailoring treatment based on individual brain responses.
Why it matters
Potential benefit: If successful, this research could lead to improved management strategies that significantly reduce the risk of secondary brain injuries in patients recovering from aSAH.
How similar studies have gone: Previous research has shown promise in using similar monitoring techniques to improve outcomes in patients with brain injuries, indicating that this approach may be effective.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Matouk, Charles — Yale University
- Study coordinator: Matouk, Charles
Related research
Other NIH-funded projects on the same topics.
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Molecularly mapping early brain injury after brain bleed using human brain organoids and patient CSF
Scientists are studying how early brain injury after aneurysmal subarachnoid hemorrhage happens in people, by using patient CSF and human brain organoids to find what signals cause damage and why women may have worse outcomes.
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Cognitive screening after an aneurysmal brain bleed
Using patient questionnaires to find thinking and memory problems in people recovering from aneurysmal subarachnoid hemorrhage.
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Understanding metabolic changes after brain hemorrhage
This study is looking at how a serious brain condition called aneurysmal subarachnoid hemorrhage affects the body's metabolism and inflammation, with the goal of finding ways to predict how well patients will recover by analyzing blood samples.
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Using Satralizumab to treat complications from brain aneurysms.
This study is looking at how well the drug Satralizumab can help people recover after a brain aneurysm by reducing complications like vasospasm, and it’s designed for patients who have had this type of hemorrhage.
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Improving cognitive assessment after brain hemorrhages for better patient outcomes
This study is looking to improve how we spot and understand thinking problems in people who have had a brain bleed, especially focusing on African American and rural patients who might not get the help they need, so we can help them live better lives.
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Blood test to predict delayed brain injury after an aneurysm bleed
This project is creating a blood test to spot which people who had a brain aneurysm bleed are likely to develop delayed brain injury in the days after the bleed.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.