Identifying brain injury risks in patients with aneurysmal subarachnoid hemorrhage using brain activity monitoring.
Electroencephalographic signatures of dysfunctional cerebrovascular autoregulation as biomarkers of brain injury in aneurysmal subarachnoid hemorrhage (SAH)
This study is looking at how to better manage blood pressure for people who have had a brain bleed from an aneurysm, by closely monitoring their brain activity to find the best targets for blood flow, which could help prevent further complications and improve recovery.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10821463 on NIH RePORTER |
What this research studies
This research investigates how abnormalities in blood flow regulation in the brain can lead to further injury in patients who have experienced an aneurysmal subarachnoid hemorrhage (aSAH). By continuously monitoring brain activity through EEG, intracranial pressure, and near-infrared spectroscopy, the study aims to personalize blood pressure management for these patients. The goal is to identify specific blood pressure targets that optimize brain blood flow and metabolism, potentially reducing the risk of complications like delayed cerebral ischemia. This innovative approach seeks to improve patient outcomes by tailoring treatment based on individual brain responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have suffered from an aneurysmal subarachnoid hemorrhage.
Not a fit: Patients who are younger than 21 years old or those who have not experienced an aneurysmal subarachnoid hemorrhage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved management strategies that significantly reduce the risk of secondary brain injuries in patients recovering from aSAH.
How similar studies have performed: Previous research has shown promise in using similar monitoring techniques to improve outcomes in patients with brain injuries, indicating that this approach may be effective.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Matouk, Charles — Yale University
- Study coordinator: Matouk, Charles
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.