Identifying brain biomarkers to improve depression treatment during pregnancy
Brain exosome biomarker targets to optimize pharmacologic treatment of depression in pregnancy
['FUNDING_R21'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-10673014
This study is looking at how certain markers in the blood of pregnant women can help predict how well antidepressants will work for them, so they can get the best treatment and keep their babies safe.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10673014 on ClinicalTrials.gov |
What this research studies
This research investigates the use of biomarkers found in exosomes from the central nervous system to predict how well antidepressant medications, specifically selective-serotonin reuptake inhibitors (SSRIs), work in pregnant women. By analyzing maternal blood samples, the study aims to understand the relationship between these biomarkers and the effectiveness of SSRI treatment for both the mother and the fetus. The goal is to develop a method to identify women who may not respond well to SSRIs and to assess the risk of neonatal withdrawal symptoms in fetuses before delivery, allowing for tailored treatment plans.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women who are being treated for depression with SSRIs.
Not a fit: Patients who are not pregnant or those who are not being treated for depression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective antidepressant treatments for pregnant women, improving outcomes for both mothers and their babies.
How similar studies have performed: While the approach of using biomarkers in exosomes is innovative, similar studies have shown promise in other areas of pharmacotherapy, indicating potential for success in this novel application.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOETZL, LAURA — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: GOETZL, LAURA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.