Identifying brain activity patterns in children with Smith Magenis syndrome
Official title: Development of quantitative EEG biomarkers for Smith Magenis syndrome
Funded at Children's Research Institute · NIH-11094222 · Data updated 2026-11-12
This study is looking at how the brains of children with Smith Magenis syndrome work during sleep compared to kids without the condition, to find patterns that could help improve treatments and support for them.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Research Institute NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $500,500 |
| NIH project number | 1R21HD117817-01 |
| Project ID | NIH-11094222 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years diagnosed with Smith Magenis syndrome.
✕Less likely to help
Patients who do not have Smith Magenis syndrome or are outside the age range of 0-11 years may not benefit from this research.
What this research studies
This research focuses on Smith Magenis syndrome (SMS), a neurodevelopmental disorder affecting children, characterized by cognitive and motor delays, speech difficulties, and severe sleep issues. The study aims to analyze EEG recordings from children with SMS and compare them to neurotypical peers to identify specific brain activity patterns. By using advanced quantitative methods, the researchers will investigate whether certain brain rhythms and sleep spindles are altered in SMS. The goal is to establish EEG biomarkers that could help in future clinical trials and therapeutic interventions for SMS.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and targeted therapies for children with Smith Magenis syndrome.
How similar studies have gone: Previous research has shown promise in identifying EEG biomarkers for other neurodevelopmental disorders, suggesting potential success for this novel approach in SMS.
Where this research is happening
-
Children's Research Institute
Washington, United States Active
Researchers
- Principal investigator: Sidorov, Michael S — Children's Research Institute
- Study coordinator: Sidorov, Michael S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.