Identifying blood proteins and fats linked to Alzheimer's disease and related dementias in older adults
Official title: Identification of plasma lipoprotein proteins and lipids as biomarkers of innate-immunity and vascular contributions to Alzheimer's disease and Alzheimer's disease-related dementias in older adults
Funded at University of Minnesota · NIH-10660037 · Data updated 2026-11-12
This study is looking at how certain proteins and fats in the blood might help us understand Alzheimer's disease and similar conditions in older adults, with the hope of finding better ways to diagnose and treat these diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $2,232,476 |
| NIH project number | 1RF1AG079100-01A1 |
| Project ID | NIH-10660037 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who are experiencing cognitive decline or are at risk for Alzheimer's disease.
✕Less likely to help
Patients who are younger than 60 or do not have any cognitive impairment may not benefit from this research.
What this research studies
This research investigates how specific proteins and fats in the blood may serve as indicators of Alzheimer's disease and related dementias in older adults. By analyzing previously collected blood samples, the study aims to uncover the relationship between these blood components and the progression of Alzheimer's disease, particularly focusing on how they relate to brain inflammation and vascular health. The goal is to enhance our understanding of Alzheimer's pathology beyond traditional markers, potentially leading to improved diagnostic and therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new biomarkers for early detection and better management of Alzheimer's disease and related dementias.
How similar studies have gone: Previous research has shown promise in identifying blood-based biomarkers for Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Li, Danni — University of Minnesota
- Study coordinator: Li, Danni
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.