Identifying blood biomarkers for Alzheimer's disease in African American and Latino populations
Official title: Peripheral and Central Biomarkers of Alzheimer's Disease in Diverse Cohorts
Funded at Mayo Clinic Jacksonville · NIH-11075375 · Data updated 2026-11-12
This study is looking for new blood tests that could help diagnose and treat Alzheimer's disease better, especially for African American and Latino communities, by examining how the disease affects these groups differently.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | March 15, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,401,655 |
| NIH project number | 5U19AG074879-03 |
| Project ID | NIH-11075375 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include African American and Latino individuals who are at risk for or diagnosed with Alzheimer's disease.
✕Less likely to help
Patients who are not part of the African American or Latino populations may not receive direct benefits from this research.
What this research studies
This research aims to investigate the biological markers associated with Alzheimer's disease specifically in African American and Latino populations, who are often underrepresented in such studies. By utilizing existing cohorts with extensive clinical and cognitive data, the project seeks to identify novel blood biomarkers that could enhance diagnosis and treatment options. The study will analyze genetic, transcriptomic, and epigenetic factors that contribute to dementia risk, leveraging data from multiple Alzheimer’s Disease research centers. Participants will contribute to a better understanding of how Alzheimer's disease manifests in diverse populations.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatment strategies for Alzheimer's disease tailored to African American and Latino patients.
How similar studies have gone: Previous research has shown success in identifying biomarkers in other populations, but this approach focusing on African American and Latino groups is relatively novel.
Where this research is happening
-
Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Carrasquillo, Minerva Maria — Mayo Clinic Jacksonville
- Study coordinator: Carrasquillo, Minerva Maria
Related research
Other NIH-funded projects on the same topics.
-
Understanding how brain activity changes may drive Alzheimer’s disease progression in a mouse model
Researchers are testing how changes in brain signals and protein cleanup processes affect the development of Alzheimer’s disease in mice.
-
Thiamine-boosting therapy for Alzheimer’s: understanding how benfotiamine may reduce harmful AGE in DP patients
A medication-based approach using high-dose vitamin B1 (benfotiamine) is studied to help people with Alzheimer's by reducing harmful sugar-related molecules.
-
Non-invasive tears biomarker for early Alzheimer's in LMICs
A low-cost, tear-based biomarker approach aims to detect early Alzheimer’s disease in older adults in Peru and similar settings.
-
Turning APOE4 into protective APOE2 or APOE3Christchurch to help with Alzheimer’s
A patient-facing explanation of a treatment idea that aims to change a genetic risk factor for Alzheimer's disease in the brain.
-
Telomerase in Alzheimer’s Disease: how aging biology could influence memory and brain health
Researchers are exploring a new brain-aging mechanism linked to telomerase, with potential to slow or modify Alzheimer’s disease in people and improve cognitive function.
-
Biomarkers of Alzheimer’s Disease: Sensory, Motor, and Cognitive Clues
Researchers are testing simple sensory and movement tasks to find early signs of Alzheimer’s disease so they can diagnose and treat people sooner.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.