Identifying biomarkers to predict outcomes from brain stimulation for epilepsy
Biomarkers to Predict Outcome from Responsive Brain Stimulation for Epilepsy
This study is looking to find ways to predict how well people with hard-to-treat epilepsy will do with a special brain device called responsive neurostimulation, so they can get the best treatment possible.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11092694 on NIH RePORTER |
What this research studies
This research aims to develop biomarkers that can predict how well patients with intractable epilepsy will respond to a brain stimulation device known as responsive neurostimulation (RNS). By analyzing clinical and electrophysiological data, the study will use machine learning techniques to create a predictive biomarker signature. This signature will help determine the most effective therapy for patients who have not responded to medication. The goal is to improve clinical decision-making and ensure that patients receive the most suitable treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with intractable epilepsy who are not suitable candidates for surgical intervention.
Not a fit: Patients who have well-controlled seizures with medication or those who are not candidates for brain stimulation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment options for patients with epilepsy, potentially improving their quality of life.
How similar studies have performed: Other research has shown promise in using biomarkers for predicting treatment outcomes in epilepsy, but this specific approach using machine learning and federated data analysis is relatively novel.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Davis, Kathryn Adamiak — University of Pennsylvania
- Study coordinator: Davis, Kathryn Adamiak
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.