Identifying biomarkers to improve treatment for coronary artery bifurcation lesions
Data-Driven Approaches to Identify Biomarkers for Guiding Coronary Artery Bifurcation Lesion Interventions from Patient-Specific Hemodynamic Models
['FUNDING_R21'] · DUKE UNIVERSITY · NIH-10681210
This study is looking at how to better treat heart problems caused by blockages at the branches of arteries, helping doctors find the best ways to improve care for patients with these tricky issues.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10681210 on ClinicalTrials.gov |
What this research studies
This research focuses on coronary artery disease (CAD), particularly the challenges associated with treating lesions that occur at arterial bifurcations. By utilizing patient-specific hemodynamic models, the study aims to develop a classification scheme that can assess the physiological severity and ischemic burden of these complex lesions. The goal is to identify biomarkers that can guide interventions and improve patient outcomes, addressing a significant gap in current treatment protocols. Patients with bifurcation lesions often face higher risks of complications, and this research seeks to provide a more effective approach to their care.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with coronary artery disease who have lesions located at arterial bifurcations.
Not a fit: Patients with coronary artery disease that do not have bifurcation lesions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols for patients with coronary artery bifurcation lesions, reducing the risk of adverse cardiac events.
How similar studies have performed: Previous research has successfully established biomarkers for simpler coronary lesions, but this approach for bifurcation lesions is novel and untested.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RANDLES, AMANDA E — DUKE UNIVERSITY
- Study coordinator: RANDLES, AMANDA E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.