Identifying biomarkers to improve Bcl2 inhibitor treatments for neuroblastoma
Mechanistic biomarkers to enable Bcl2 inhibitor therapies for neuroblastoma
This study is looking at how to better treat neuroblastoma, a childhood cancer, by finding specific markers in cancer cells that can help doctors know which kids will benefit most from a new type of treatment that helps kill cancer cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11015933 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain proteins in cancer cells can be targeted to improve treatment outcomes for neuroblastoma, a type of childhood cancer. The study aims to identify specific biomarkers that can predict which patients will respond best to Bcl2 inhibitor therapies, which work by triggering cancer cell death. By creating models from patient-derived tumors, researchers will test these biomarkers and develop diagnostic tools to enhance the effectiveness of these treatments. The ultimate goal is to make Bcl2 inhibitors a viable option for more patients suffering from neuroblastoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with neuroblastoma who may benefit from targeted therapies.
Not a fit: Patients with neuroblastoma who do not express the relevant biomarkers or have other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for children with neuroblastoma.
How similar studies have performed: Other research has shown promising results with Bcl2 inhibitors in different cancer types, indicating potential for success in neuroblastoma as well.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Hogarty, Michael D — Children's Hosp of Philadelphia
- Study coordinator: Hogarty, Michael D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.