Identifying biomarkers that predict the development of type 1 diabetes in children
Official title: Systematic validation of biomarkers predictive of IA and T1D and their relationship with disease development
Funded at Battelle Pacific Northwest Laboratories · NIH-11012399 · Data updated 2026-11-12
This study is looking at how to better predict type 1 diabetes in kids by checking their blood for certain proteins, which could help doctors catch the disease earlier and manage it more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Battelle Pacific Northwest Laboratories NIH-funded |
| Lab location | 1 site (Richland, United States) |
| Project start | January 17, 2024 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $691,441 |
| NIH project number | 5R01DK138335-02 |
| Project ID | NIH-11012399 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0 to 21 years who are at risk for type 1 diabetes or have shown early signs of islet autoimmunity.
✕Less likely to help
Patients who are older than 21 years or do not have any family history of type 1 diabetes may not benefit from this research.
What this research studies
This research focuses on understanding type 1 diabetes (T1D), a condition where the immune system attacks insulin-producing cells in the pancreas. By analyzing blood samples from children, the study aims to identify new biomarkers that can predict the onset of islet autoimmunity and the progression to T1D. The researchers have already found several proteins that show promise in predicting these conditions and will use advanced machine learning techniques to enhance the accuracy of their predictions. This could lead to earlier interventions and better management of the disease.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and intervention for children at risk of developing type 1 diabetes, potentially improving their quality of life.
How similar studies have gone: Previous studies have successfully identified biomarkers related to autoimmune diseases, indicating that this approach has potential for success.
Where this research is happening
-
Battelle Pacific Northwest Laboratories
Richland, United States Active
Researchers
- Principal investigator: Nakayasu, Ernesto Satoshi — Battelle Pacific Northwest Laboratories
- Study coordinator: Nakayasu, Ernesto Satoshi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.