Identifying biomarkers related to memory issues in temporal lobe epilepsy
Official title: Molecular Profiling and Biomarkers of Memory Phenotypes in Temporal Lobe Epilepsy
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-10979812 · Data updated 2026-11-12
This study is looking at how memory problems in adults with tough-to-treat temporal lobe epilepsy might be linked to changes in their genes and proteins, so we can find better ways to help those who struggle with memory, even if they seem okay on the surface.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $577,978 |
| NIH project number | 1R01NS135080-01A1 |
| Project ID | NIH-10979812 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with temporal lobe epilepsy, particularly those with pharmacoresistant mesial TLE and hippocampal sclerosis.
✕Less likely to help
Patients with temporal lobe epilepsy who do not experience memory deficits or have other unrelated neurological conditions may not benefit from this research.
What this research studies
This research focuses on understanding the memory deficits associated with temporal lobe epilepsy (TLE), particularly in adults who have pharmacoresistant mesial TLE and hippocampal sclerosis. The study aims to identify molecular biomarkers that can predict memory impairment, even in patients who appear to have intact memory despite significant brain damage. By analyzing blood samples and brain tissue, researchers will explore the genetic and protein expressions linked to memory function. The ultimate goal is to develop personalized prognostic models that can inform treatment strategies for those affected by memory dysfunction due to TLE.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for patients with memory impairments related to temporal lobe epilepsy.
How similar studies have gone: Previous research has shown promise in identifying biomarkers for neurological conditions, suggesting that this approach could yield valuable insights, although the specific focus on TLE and memory dysfunction is relatively novel.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Busch, Robyn M — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Busch, Robyn M
Related research
Other NIH-funded projects on the same topics.
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Epilepsy Data Ecosystem: A Big-Data Sharing Platform for Better Care
A national effort to collect and share large, multi‑modal brain data from people with medication‑resistant epilepsy to speed discoveries and improve treatment options.
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Exploring epilepsy genes in zebrafish to understand human brain seizures
A study in zebrafish will model human epilepsy genes to help explain how certain brain mutations contribute to seizures.
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New MRI tools to better plan pediatric epilepsy surgery
A new MRI-based approach helps doctors decide the best time to surgically remove brain tissue in children with difficult-to-control seizures.
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Sahel Epilepsy Study: finding patterns in epilepsy in rural Africa and its links to genes
A plan to study epilepsy in rural Nigeria to discover how common it is, what factors affect risk, and how genetics may influence it, with results that could improve care for people with epilepsy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.