Identifying biomarkers in brain tissue related to aging and Alzheimer's disease
Supplement-Discovery and Validation of Epigenetic Biomarkers in Brain Tissue
This study is looking at how chronic pain might affect brain aging and thinking skills in older adults, especially those with Alzheimer's and similar conditions, by examining brain tissue, blood samples, and brain scans to find clues that could help us understand this connection better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10939464 on NIH RePORTER |
What this research studies
This research investigates the relationship between chronic pain, biological aging, and cognitive decline in older adults, particularly those with Alzheimer's disease and related dementias. By analyzing brain tissue and blood samples, the study aims to identify epigenetic biomarkers that could indicate accelerated brain aging. The researchers will also utilize clinical MRIs to assess brain aging in participants, providing a comprehensive view of how pain may influence cognitive health. This approach seeks to fill a critical gap in understanding the complex interactions between pain and cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and over, particularly those experiencing chronic pain or at risk for Alzheimer's disease and related dementias.
Not a fit: Patients under the age of 65 or those without chronic pain or cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new biomarkers that help predict cognitive decline in older adults, potentially improving early diagnosis and treatment strategies for Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in identifying biomarkers related to cognitive decline, suggesting that this approach may yield valuable insights.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Cruz-Almeida, Yenisel — University of Florida
- Study coordinator: Cruz-Almeida, Yenisel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.