Identifying biomarkers for tuberculosis using plasma metabolomics
High resolution plasma metabolomics to identify biomarkers of tuberculosis
This study is looking at how certain substances in the blood can help us find out if someone has active tuberculosis (TB) or is at risk of developing it, with the hope of creating better tests to catch TB early, especially in places where healthcare resources are limited.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10690476 on NIH RePORTER |
What this research studies
This research investigates how high-resolution metabolomics can uncover metabolic signatures linked to active tuberculosis (TB) and latent TB infections that may progress to active disease. By analyzing plasma samples from unique clinical cohorts, the study aims to identify specific metabolites from both the host and the Mycobacterium tuberculosis bacteria. The goal is to develop reliable biomarkers that can lead to improved diagnostic tests for TB, particularly in resource-limited settings. This approach could enhance early detection and treatment strategies for individuals at risk of developing active TB.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are at risk of tuberculosis, particularly those with latent TB infections.
Not a fit: Patients who are not at risk for tuberculosis or those who have already been diagnosed and treated for active TB may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new diagnostic tools that allow for earlier and more accurate detection of tuberculosis.
How similar studies have performed: Previous research has shown promise in using metabolomics to identify biomarkers for various diseases, suggesting that this approach may yield valuable insights for tuberculosis as well.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Collins, Jeffrey M — Emory University
- Study coordinator: Collins, Jeffrey M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.