Identifying biomarkers for tuberculosis infection in young children with and without HIV
Official title: Biomarker Signatures of TB Infection in Young Children With and Without HIV
Funded at Rutgers Biomedical and Health Sciences · NIH-11060942 · Data updated 2026-11-12
This study is looking for ways to find signs of tuberculosis (TB) in young children under 5, especially those who are HIV positive, to make it easier and more accurate to diagnose TB without uncomfortable tests.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | April 28, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,016,533 |
| NIH project number | 5R01AI175315-03 |
| Project ID | NIH-11060942 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 5 years old who have been exposed to tuberculosis, including those with HIV.
✕Less likely to help
Patients who are older than 11 years or those without any exposure to tuberculosis may not benefit from this research.
What this research studies
This research investigates how to identify specific biomarkers that can indicate tuberculosis (TB) infection in young children, particularly those under 5 years old, including those who are HIV positive. The study aims to improve diagnostic methods that are currently inadequate for this age group, as existing tests often require uncomfortable procedures and may not accurately detect TB. By focusing on children who are close contacts of TB cases, the research seeks to differentiate between those who have subclinical TB and those who do not, ultimately aiming to enhance treatment strategies and preventive measures.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and less invasive diagnostic methods for TB in young children, potentially saving lives.
How similar studies have gone: Other research has shown promise in identifying biomarkers for TB in adults, but this specific approach in young children is relatively novel.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Salgame, Padmini — Rutgers Biomedical and Health Sciences
- Study coordinator: Salgame, Padmini
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.