Identifying biomarkers for the transition from acute to chronic pain

Clinical Coordinating Center for the Acute to Chronic Pain Signatures Program

NIH-funded research University of Iowa · NIH-10684372

This study is looking at why some people with short-term pain end up with long-lasting pain, and it aims to find ways to tailor treatments to help those individuals, all while reducing the need for opioids.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of Iowa NIH-funded
Lab location1 site (Iowa City, United States)
Project IDNIH-10684372 on NIH RePORTER

What this research studies

This research focuses on understanding how some individuals transition from experiencing acute pain to developing chronic pain. By identifying specific biomarkers that indicate susceptibility or resilience to chronic pain, the study aims to personalize treatment strategies for acute pain. The research involves a large consortium of pain scientists and utilizes multisite observational studies to gather comprehensive data across various factors affecting pain. This approach seeks to reduce reliance on opioids and discover new therapeutic targets for pain management.

Who could benefit from this research

Good fit: Ideal candidates for this research include individuals who have recently experienced acute pain and are at risk of developing chronic pain.

Not a fit: Patients with pre-existing chronic pain conditions may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to more effective and personalized pain management strategies, reducing the risk of chronic pain development.

How similar studies have performed: Other research has shown promise in identifying biomarkers for pain management, making this approach both relevant and potentially impactful.

Where this research is happening

Iowa City, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.